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KMID : 0381219920240040444
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Journal of RIMSK
1992 Volume.24 No. 4 p.444 ~ p.452
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The Effects of PEEP on CVP and PCWP in Oleic Acid Induced Pulmonary Edema in Dogs
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Abstract
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Oleic acid(OA) administered to experimental animals increases pulmonary vascular permeability and produces a condition that pathophysiologically resembles adult respiratory distress syndrome(ARDS) in humans. Because of the marked physiologic and
pathologic similarities between OA injury and ARDS, OA has been employed in various animals as a model of ARDS.
During mechanical ventilation with PEEP, hypoxemia is improved through an increase in the functional residual capacity of the lung and a decreased in small airway closure, thus allowing a better matching of ventilation to perfusion. Despite an
improvement in arterial oxygenation, the use of PEEP may be accompanied by profound cardiovascular changes.
The auther investigated the sequence of the effects of 5, 10, 15, and 20 cm H2O PEEP on the blood pressure and hart rate, arterial blood gases, central venous pressure(CVP) and pulmonary capillary wedge pressure(PCWP) after oleic acid injury in
10
Korean mongreal dogs.
@ES The results were as follows:
@EN 1) the systolic, diastolic, and mean arterial presure showed no significant change after oleic acid injection(0.05 ml/kg) and below 10 chH2O PEEP, but diastolic and mean arterial pressure decreased significantly with 15~20 cmH29 PEEP therapy.
2) heart rate significantly decreased after oleic acid injectio and PEEP therapy.
3) CVP and PCWP revealed no significant change after oleic acid injection but gradually increased following PEEP therpy.
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KEYWORD
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